Introduction
- Systems Biology
- Bio-Inspired Engineering
- Research Interests
Research Focuses
- Signal Transduction Pathways
- Biomolecular Regulatory Networks
- Complex Cellular Dynamics
- Brain Systems Biology
- Cancer Systems Biology
- Cardiac Systems Biology
- Network Systems Biology
- Pregnosis
- Bio-inspired Self-Repairing Electronic Circuits
- Brain-inspired Speech Recognition System
Funded Research Projects
Software
- SBIE Software
- Source Codes of Publications
Research Equipments
Useful Information for Systems Biological Research and Links
Funded Research Projects
  1. Development of a control strategy for brain disease based on dynamic analysis of brain networks (Korea Institute of Science and Technology Information, KISTI), Co-Principal Investigator, May 2017 - Nov. 2017 (ca. $90,000).


  2. Automatic segmentation of blood vessels in heart using deep-learning based on CT image (SiliconSapiens Corp., Korea), Principal Investigator, Nov. 2016 - Oct. 2017 (ca. $70, 000).


  3. Systems biological study on the reverse control of dermal fibroblast aging (AMOREPACIFIC Co., Korea), Principal Investigator, Nov. 2016 - Oct. 2017 (ca. $50, 000).


  4. Systems biological research to identify effective molecular targets for reactivation of hair stem cells (AMOREPACIFIC Co., Korea), Principal Investigator, May 2016 - April 2018 (ca. $100,000).


  5. Development of a simulation platform for optimal anticancer chemotherapy based on control analysis of molecular interaction networks of cancer (Ministry of Science, ICT & Future Planning), Principal Investigator, Nov. 2015 - July 2017 (ca. $1,000,000).


  6. Development of molecular network simulation platform for personalized medicine based on big data of genomic variation (KAIST), Principal Investigator, June 2015 - Dec. 2017 (ca. $ 140,000).


  7. Investigation into the core regulatory mechanism and systematic control of cancer signaling network based on computational systems biology (Ministry of Science, ICT & Future Planning), Principal Investigator, Nov. 2014 - Oct. 2017 (ca. $882,000).


  8. Prediction of prototypic yield production based on network modeling and development of risk-minimization technology (Samsung Electronics Co., Ltd.), Principal Investigator, July 2014 - June 2016 (ca. $220,000).


  9. Development of a new imaging modality, "Neuronal Resonance MRI" (Samsung Electronics Co., Ltd.), Co-Principal Investigator, June 2014 - June 2017 (ca. $604,197).


  10. Development of personalized precision cancer therapeutics system based on genomic-convergence systems informatics (Ministry of Health and Welfare), Co-Principal Investigator, Dec. 2013 - Nov. 2017 (ca. $400,000).


  11. Network-based deciphering of non-coding genomic variations (Ministry of Health and Welfare), Co-Principal Investigator, Dec. 2013 - Nov. 2016 (ca. $450,000).


  12. A study on simulation platform for cell signaling (Samsung Electronics Co., Ltd.), Principal Investigator, Sept. 2013 - Sept. 2014 (ca. $90,000).


  13. A systems biological study to analyze the pathogenesis of heart failure and to develop the personalized therapeutic strategy based on mathematical modeling and computer simulation (Ministry of Science, ICT & Future Planning), Principal Investigator, Aug. 2013 - July 2017 (ca. $955,000).


  14. Development of disease network simulation platform for personalized medicine based on big data analysis (KAIST), Principal Investigator, May 2013 - July 2015 (ca. $145,000).


  15. A study on the human disease network model and its dynamic simulation for systems healthcare (KAIST), Co-Principal Investigator, Jan. 2013 - Dec. 2017 (ca. $457,000).


  16. A system-level BIT convergence study on cell fate determination (KAIST), Principal Investigator, May 2011 - Dec. 2014 (ca $45,000).


  17. A study on the IR-induced genomic surveillance system and its control (Nuclear Research Grant - Phase II: Ministry of Education and Science & Technology), Co-Principal Investigator (Coordinator: Dr. Deog-Su Hwang), April 2011 - March 2013 (ca. $600,000).


  18. A de novo systems biological study of cancer signaling pathway based on high precision measurement of molecular interactions for personalized systems medicine (KAIST Institute Brand Project, KAIST), Principal Investigator, Jan. 2011 - Dec. 2012 (ca. $555,000).


  19. A systems biological study for cosmetic whitening target identification based on molecular network modeling (AMOREPACIFIC Co., Korea), Principal Investigator, May 2011 - Oct. 2013 (ca. $120,000).


  20. A study on virtual cancer cell based on systems biology (NRL: National Research Laboratory Project, Ministry of Education and Science & Technology), Principal Investigator, May 2010 - April 2015 (ca. $1,500,000).


  21. Investigations into the disease mechanism of the calcium signaling system based on mathematical modeling and dynamical analysis (Korean Systems Biology Initiative – Phase III: Ministry of Education and Science & Technology), Principal Investigator, April 2010 - March 2012 (ca. $340,000).


  22. Development and validation of the evaluation method for the renal toxicity using virtual cell model (National Institute of Food and Drug Safety Evaluation), Co-Principal Investigator(Coordinator: Prof. En-Bo Shim), April 2010 - Nov. 2012 (ca. $150,000).


  23. Development of modeling and simulation platform technologies for systems biology based on experimental data (Gwangju Institute of Science and Technology, GIST), Principal Investigator, Jan. 2010 - Dec. 2015 (ca. $235,000).


  24. Mathematical modeling of MDMA toxicity at gene expression level (National Institute of Food and Drug Safety Evaluation), Principal Investigator, Sept. 2009 - Dec. 2009 (ca. $29,500).


  25. Development of bio-circuit simulation IT-converging platform technologies for bio-medical applications (BRL: Basic Research Laboratory Project, Ministry of Education and Science & Technology, Korea), Principal Investigator, Sept. 2009 - March 2014 (ca. $2,259,000).


  26. A preliminary study for the development of biosimulation platform technology (ICC New Technology Development Project, KAIST), Project Coordinator & Principal Investigator, July 2009 - Dec. 2010 (ca. $100,000).


  27. Development of simulation technology for body effects of exercise programs (Ministry of Culture, Sports and Tourism), Co-Principal Investigator (Coordinator: Prof. Jae Hyeng Im), July 2009 - June 2012 (ca. $900,000).


  28. A systems biological study on the topology and function of Schizophrenia neural networks (Translational Research Center, Ministry of Health, Welfare and Family Affairs), Principal Investigator, May 2009 - March 2013 (ca. $470,000).


  29. A study on the IR-induced genomic surveillance system and its control (Nuclear Research Grant - Phase II: Ministry of Education and Science & Technology), Co-Principal Investigator (Coordinator: Dr. Deog-Su Hwang), April 2009 - March 2013 (ca. $280,000).


  30. In silico developmental toxicity evaluation system (II) (National Institute of Toxicological Research), Project Coordinator & Principal Investigator, March 2009 - Nov. 2009 (ca. $120,000).


  31. A preliminary study for the development of electronic cancer system (Research Project of KI for IT Convergence, KAIST), Principal Investigator, Jan. 2009 - Dec. 2009 (ca. $50,000).


  32. Development of a bio-inspired self-repairing electronic circuit (Undergraduate Research Program, KAIST), Supervisor, Dec. 2008 - May 2009 (ca. $2,000).


  33. Multi-scale neuro-informatics techniques for targeted therapy of dopamine-related brain disorders (WCU: World Class University Project, Ministry of Education and Science & Technology, Korea), Co-Principal Investigator, Dec. 2008 - Nov. 2013 (ca. $3,675,000).


  34. Towards a multi-scale computational model of intestinal crypt dynamics and the progression to cancer (PMI2 Strategic Alliances and Partnerships Project, Research Co-Operation Strand, British Council, London, U.K.), Co-Principal Investigator, May 2008 - April 2010 (40,000 GBP [Korea - U.K. Joint Research Project (KAIST & University of Oxford)]).


  35. Development of an omics data integration technology platform and its application to the analysis of molecular interaction networks of microbes (The 21C Frontier Microbial Genomics and Application Center Program, Ministry of Education and Science & Technology), Principal Investigator, April 2008 - March 2012 (ca. $320,000).


  36. In silico developmental toxicity evaluation system (National Institute of Toxicological Research), Project Coordinator & Principal Investigator, March 2008 - Nov. 2008 (ca. $120,000).


  37. Development of information technology and its application for systems biology (Super Computer Application Research Project, KISTI Super Computing Center), Co-Principal Investigator, Feb. 2008 - Nov. 2008 (ca. $85,000).


  38. Development of modeling and simulation platform technologies for systems biology based on experimental data (Systems Biology Infrastructure Development Project, GIST - Ministry of Education and Science & Technology), Principal Investigator, Jan. 2008 - Dec. 2010 (ca. $120,000).


  39. Identification of cancer drug target based on small GTPase (Research Project of KI for the BioCentury, KAIST), Co-Principal Investigator, Jan. 2008 - Dec. 2008 (ca. $60,000).


  40. Investigations into the disease mechanism of the calcium signaling system based on mathematical modeling and dynamical analysis (Korean Systems Biology Initiative - Phase III: Ministry of Education and Science & Technology), Principal Investigator, April 2007 - March 2010 (ca. $300,000).


  41. A study on the IR-induced genomic surveillance system and its control (Nuclear Research Grant - Phase I: Ministry of Education and Science & Technology), Co-Principal Investigator (Coordinator: Dr. Deog-Su Hwang), April 2007 - March 2009 (ca. $615,000).


  42. A fundamental study on toxicology through in silico investigations: TRC (National Institute of Toxicological Research), Project Coordinator & Principal Investigator, May. 2006 - Nov. 2007 (ca. $365,000).


  43. Dynamical analysis of the cross-talks among the signaling pathways related to colorectal cancer and systems biological investigations for identification of new drug targets (The Korea Bio-Hub Research Program, Ministry of Commerce, Industry and Energy), Project Coordinator & Principal Investigator, Jan. 2006 - Dec. 2007 (ca. $140,000).


  44. A fundamental study on toxicology through in silico investigations (I): TRC (National Institute of Toxicological Research), Project Coordinator & Principal Investigator, May 2006 - Nov. 2006 (ca. $170,000).


  45. Unraveling the regulatory network of two-component systems in E. coli and the dynamical analysis of the embedded cross-talk based on mathematical modeling (The 21C Frontier Microbial Genomics and Application Center Program, Ministry of Science and Technology), Principal Investigator, April 2005 - March 2008 (ca. $205,000).


  46. Identification of interaction networks and dynamical analysis of the calcium signaling system (Korean Systems Biology Initiative - Phase II: Ministry of Science and Technology), Principal Investigator, April 2005 - March 2007 (ca. $200,000).


  47. Application of control engineering principles to molecular biological systems (Korea Science and Engineering Foundation), Principal Investigator, Apr. 2004 - Mar. 2007 (ca. $75,000, but stopped in Aug. 2004 due to my movement from Ulsan to Seoul).


  48. Analysis, modeling, and simulation of dynamics in the calcium signal transduction pathways (Korean Systems Biology Initiative - Phase I: Ministry of Science and Technology), Principal Investigator, June 2003 - March 2005 (ca. $100,000).


  49. Design and implementation of integrated Fieldbus network systems (Korea Science and Engineering Foundation), Researcher, Mar. 2003 - Feb. 2005 (ca. $40,000).


  50. Critical dimension control of semiconductor photolithographic processes (Samsung Electronics Co., Ltd.), Principal Investigator, Apr. 2002 - Dec. 2002 (ca. $55,000).


  51. A study on network design and efficient network management (IV): Fault analysis and diagnosis in optical multistage interconnection networks (Ministry of Information and Communication), Co-Principal Investigator, June 2001 - May 2002 (ca. $20,000).


  52. Integrated supervisory control of multi-agent systems: Theory and applications (Korea Research Foundation), Principal Investigator, Oct. 2001 - Sept. 2003 (ca. $40,000).


  53. Development of navigation, communication, and porter control system technology for autonomous guided vehicles (Hyundai Heavy Industries Co., Ltd.), Co-Principal Investigator, Nov. 2000 - Dec. 2001 (ca. $20,000).


  54. Supervisory intelligent control of semiconductor photolithographic processes (Samsung Electronics Co., Ltd.), Principal Investigator, Aug. 2000 - Jan. 2001 (ca. $55,000).


  55. A study on network design and efficient network management (III): Consolidation for multicasting in ATM networks (Ministry of Information and Communication), Co-Principal Investigator, June 2000 - May 2001 (ca. $20,000).


  56. Design of programmable logic controllers for automated robot systems in production lines (Ace Robotech. Co., Ltd. and Small & Medium Business Administration), Principal Investigator, Dec. May 2000 - Apr. 2002 (ca. $40,000).


  57. Multiagent fault-tolerant supervisory control of serial production systems under partial observation (Korea Research Foundation), Principal Investigator, Dec. 1999 - Nov. 2000 (ca. $15,000).


  58. Supervisory control of multiple mobile robots for automated manufacturing systems and ports (Ministry of Commerce, Industry, and Energy), Principal Investigator, Dec. 1999 - Apr. 2000 (ca. $15,000).


  59. A study on network design and efficient network management (II): Design and implementation of control networks for factory automation (Ministry of Information and Communication), Co-Principal Investigator, June 1999 - May 2000 (ca. $20,000).


  60. Failure diagnosis and fault-tolerant supervisory control of semiconductor manufacturing systems (Korea Science and Engineering Foundation), Researcher, Sept. 1996 - Aug. 1999 (ca. $60,000).


  61. Fault-tolerant supervisory control of discrete event dynamic systems (Korea Research Foundation), Researcher, Aug. 1996 - July 1998 (ca. $45,000).


  62. Supervisory control of FMS for CIM with MIQ(Machine IQ) measure (LG Industrial Systems Co., Ltd.), Researcher, Oct. 1995 - Sept. 1997 (ca. $20,000).


  63. Development of predictive diagnostic system for thermal power plant (I) (Korea Electric Power Corporation), Researcher, Apr. 1994 - Apr. 1996 (ca. $40,000).


  64. Performance improvement of semiconductor manufacturing systems using fuzzy logic controller (Korea Science and Engineering Foundation), Researcher, Aug. 1993 - Jul. 1994 (ca. $15,000).